Similar to a word like “value,” clinical benefit can take on different meanings based on each stakeholders’ perspective.
For the patient, clinical benefit is about improved outcomes (lessened pain, slowed progression of disease, symptom relief, etc.).
For the innovator, clinical benefit refers to whether a product has a favorable benefit-risk profile (weighing the potential benefits with potential risks), whether it can be recommended according to guidelines, and whether clinicians are impressed with the product.
For payers, clinical benefit concerns the proven efficiency and durability of a product or service in regard to patient outcomes.